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Safety of Dietary Supplements
Generally health supplements is very safe as compare to pharmaceutical drugs
It’s fascinating how when there is one suspected adverse reaction to a dietary supplement it makes the headlines, and yet officials and the media are oblivious to the plethora of deaths due to properly regulated, properly prescribed and properly used drugs – not to mention avoidable deaths due to medical misadventure. This graph highlights the relative safety of dietary supplements compared to many other causes of death. Although they are USA figures, by and large they compare with NZ figures.
Figure 1: Statistical comparison of frequent causes of death (USA)
Figure 1a: Risk of supplements relative to other factors (New Zeland 2002)
Figure 2: Societal vs Individual Risk in Australia (2004)
Figure 3: Iatrogenic Injury in Australia Relative Risks of Selected Activities in Aus Govt Report
Figure 4: How safe is safe enough? - Number of encounters for each fatality (Law, modified Amalberti, Leape)
Figure 5: Risk of Dying in Canada Compared to Being Killed on a Boeing 747 Flight
Figure 6: Relative Risks of Hospital Care, Pharmaceutical Drugs, Traffic Accidents, Foods, and Dietary Supplements in New Zealand (Ron Law 2004)
In the Safety of Supplements article by Robert Ryan, he compared the the safety of supplements with pharmaceutical drugs and fast food. A 1998 study in the JAMA stated in a single year in the USA, “2,216,000 hospitalised patients had serious Adverse Drug Reactions and 106,000 had fatal Adverse Drug Reactions." The study concludes that reactions to pharmaceutical drugs are "between the fourth and sixth leading cause of death.“1
What about eating fast food, it is dangerous? "Every day in the United States, roughly 200,000 people are sickened by a foodborne disease, 900 are hospitalised, and 14 die."2
In 2004 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System (TESS), not a single death was reported from an adverse reaction or unintended cause from the consumption of dietary supplements (vitamins, minerals, antioxidants, and herbal supplements). When viewed on a risk management continuum from one to ten, where one means risk-free and ten means high risk, vitamins, minerals, and herbal supplements would fall between one and three. Over-the-counter non-steroidal anti-inflammatories (OTC NSAIDs), such as aspirin, ibuprofen, and naproxen, would comprise the middle ground. Prescription drugs, on the other hand, would span the upper limits of risk.3
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Vets have long known and recommended not to feed your nutrient deficient leftovers to your pets – they’ll get sick – so... all commercially prepared pet foods contain dietary supplements. Cattle, sheep, horses, goats, laboratory rabbits & rats etc need dietary supplements to remain healthy. We’ve long known that pastures and crops need dietary supplements (fertiliser) to grow well. Yet it is still denied by officials that humans need dietary supplements – despite the plethora of evidence and commonsense that says otherwise. Our regulators are tying to convince use that despite the fact that our pets need supplements, our farm animals need supplements, our crops need supplements – humans don’t.
Harvard University recently released a report on the prevention of cancer of the colon. Top of the pops were exercise and longterm folic acid containing multivitamin supplementation. Harvard University has been undertaking a longitudinal study of nearly 100,000 nurses for about twenty years. Their research has shown that the impact of folic acid supplementation reduces cancer of the colon by a massive 75-80%. (See figure 2.)
At the same time John Hopkin’s Medical Center’s nutrition department recently stated, “Based on studies where people take a supplement, vitamin E seems to reduce risk of some cancers by 60 to 70 percent. Increased levels of vitamin E also appear to decrease the amount of fat (lipids) in the arteries, and to reduce the risk of heart disease by 80 to 90 percent.” WOW! They then go on to say that they don’t recommend supplements. Hello?

Larry Clark from Arizona University found, in a controlled multi centre study, that a daily selenium supplement cut cancer mortality in half, leading at the same time to a 46-63 percent reduction in the incidence of lung-, prostate-, and colorectal cancer. (www.selenium.org) Given that New Zealand has one of the highest rates of all three cancers, and given that the cure rates for these three forms of cancer are relatively low, less than 10% for lung cancer, and about 50% for bowel cancer, it makes sense to recommend folic acid and selenium supplements to your customers. Ask them what they would prefer, lowering the risk of getting and dying from cancer by 50% or get it and then have less than a 50% chance of a cure? Not to mention the unpleasant treatment, nor the fact that 20% of cancer suffers get a second cancer due to their treatment without being told this fact.
Eat right and take a Multivitamin [with folic acid].
“The current evidence suggests that people who take such supplements and their children are healthier.” Dr G Oakley from the Center for Disease Control talking about ‘standard’ multivitamins with 400 ug of folic acid. NEJM, April 1998.
If every one in NZ took a multivitamin....
This article was prepared by Ron Law, former executive director of the New Zealand National Nutritional Foods Association and member of a New Zealand government working group advising on strategies for reducing medical error